“These are men (and women) with bold ideas, but highly critical of their own idea; they try to find whether their ideas are right by trying first to find whether they are not perhaps wrong. They work with bold conjectures and severe attempts at refuting their own conjectures.”

— Karl Raimund Popper

'Replies to my Critics', in P. A. Schilpp (ed.), The Philosophy of Karl Popper (1974), Book 2, 977-8


Principal Investigator

Daniel De Carvalho, PhD.
Scientist, Ontario Cancer Institute/Princess Margaret Hospital
Assistant Professor, Department of Medical Biophysics, Faculty of Medicine, University of Toronto.
e-mail: ddecarv[at]uhnresearch.ca
Webpage: OCI profile, PMH profile, UofT profile

Administrative Assistant

Susan Alexander
Sue oversees all the administrative operations of the lab.
e-mail: alexande[at]uhnresearch.ca

Postdoctoral Fellows

Rajat Singhania, PhD.
Rajat is a computational biologist with experience in mathematical models of biological processes. He has a bachelor’s degree in computer science and a PhD in computational biology from the prestigious Virginia Tech University. Rajat is interested in computational epigenetics and his work aims to understand the process of epigenetic reprogramming in cancer.
e-mail: rajitz[at]gmail.com


David Roulois, PhD.
David is a cell biologist with experience in immunology and immune therapy. He obtained his bachelor’s degree and master degree in Cellular and Molecular Biology from Université de Rennes 1 (France) and a PhD in cell biology from Université de Nantes (France). David is interested in study how epigenetic drugs can modulate the T cell immune response against cancer cells.
e-mail: droulois[at]uhnresearch.ca


Constanze Zeller, PhD.
Constanze is a molecular biologist with experience in cancer epigenetics. She has a PhD in cell biology from Humboldt University and Max Delbrueck Center in Berlin and a postdoctoral trainning at Prof. Robert Brown's lab at Imperial College London. Constanze is interested in uncover new targets and pathways for cancer epigenetic therapy.
e-mail: czeller[at]uhnresearch.cam


Tiago Medina, PhD.
Tiago is an immunologist with experience in T cell biology. He obtained his PhD from University of Sao Paulo (Brazil). Tiago is interested in study the epigenome of different T cell populations and its relationship to the microbiome.
Tiago is funded by the Science Without Borders Fellowship
e-mail: tmedina[at]uhnres.utoronto.ca


Aline C. Planello, PhD.
Aline obtained her PhD from University of Campinas, UNICAMP (Brazil), with experience in cancer epigenetics. She is interested in investigate the molecular mechanism of polycomb regulation in cancer and stem cell biology
Aline is funded by the the BEPE fellowship (FAPESP foundation)
e-mail: alineplanello[at]gmail.com


Graduate Students

Helen Loo Yau
MSc. Candidate, University of Toronto, Medical Biophysics Department.
Helen holds Bachelor in Sciences (Hons) from University of Toronto with specialization in Immunology. Helen is interested in study how epigenetic drugs can modulate the T cell immune response against cancer cells.
Helen is funded by the MBP Visa differential scholarship and MBP Excellence award, a merit-based scholarship funded by the Department of Medical Biophysics and the University of Toronto Fund
e-mail: hehe.looyau[at]mail.utoronto.ca


Shengrui (Frank) Feng, MSc.
PhD. Candidate, University of Toronto, Medical Biophysics Department.
Frank holds B.Sc. cum laude, Honors Program in Biological Science, Southwest University, Chongqing, China and a master degree (MSc) from University of Ottawa. Frank is interested in identify the mechanisms underlying PRC1/2 recruitment to the chromatin and global PRC1/2-reprogramming in brain tumours. Frank is funded by the MBP Excellence award, a merit-based scholarship funded by the Department of Medical Biophysics and the University of Toronto Fund
e-mail: shengrui.feng[at]mail.utoronto.ca


Laboratory Technicians

Shu Yi (Roxana) Shen
Roxana is trying to identify new DNA methylation biomarkers for pancreatic cancer using circulating tumor DNA.
e-mail: rshen[at]uhnres.utoronto.ca


Lab Alumni

Lisa Bloomer, PhD.
Knudson Postdoctoral Fellow (2013-2014)
Current position: Learning Support Tutor at Truro College (UK).