Selected Publications

  • David Roulois, Helen Loo Yau, Daniel D. De Carvalho. Pharmacological DNA Demethylation: Implications for Cancer Immunotherapy. OncoImmunology. in press.
    PubMed | PDF

  • David Roulois, Helen Loo Yau, Rajat Singhania, Yadong Wang, Arnavaz Danesh, Shu Yi Shen, Han Han, Gangning Liang, Peter A. Jones, Trevor J. Pugh, Catherine O’Brien, Daniel De Carvalho. DNA-demethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts. Cell. 2015 Aug 27;162(5):961-73.
    PubMed | PDF
    Preview by Jonathan D. Licht at Cell
    Selected as one of the top 10 "2015 notable advances" by Nature Medicine: "Immuno-oncology: Going viral"
    Featured by Faculty of 1000 post-publication peer review

  • Emma Strong, Darci T Butcher, Rajat Singhania, Carolyn B Mervis, Colleen A Morris, Daniel De Carvalho, Rosanna Weksberg, Lucy R Osborne. Symmetrical dose-dependent DNA methylation profiles in children with deletion or duplication of chromosome 7q11.23. The American Journal of Human Genetics. 2015 Aug 6;97(2):216-27.
    PubMed | PDF

  • Luciana Benevides, Denise M. da Fonseca, Paula B. Donate, Daniel G. Tiezzi, Daniel D. De Carvalho, Jurandyr M. de Andrade, Gislaine A. Martins, Joao S. Silva. IL-17 promotes mammary tumor progression by changing the behavior of tumor cells and eliciting tumorigenic neutrophils recruitment. Cancer Research. 2015 Sep 15;75(18):3788-99.
    PubMed | PDF

  • Yang X*, Han H*, DD De Carvalho*, Lay FD, Liang G, Jones PA. Gene Body Methylation can Alter Gene Expression and is a Therapeutic Target in Cancer. Cancer Cell. 2014 Oct 13;26(4):577-90.
    PubMed | PDF
    Preview by Kasinathan and Henikoff at Cancer Cell
    Highlighted by Nature Reviews Genetics

  • De Souza AP, Planello AC, Marques MR, De Carvalho DD, Line SRP. High-Throughput DNA Analysis Shows the Importance of Methylation in the Control of Immune Inflammatory Gene Transcription in Chronic Periodontitis. Clinical Epigenetics. 2014 August 12; 6:15.
    PubMed | PDF

  • Fukumasu H, Rochetti AL, Pires PR, Silva ER, Mesquita LG, Strefezzi RF, De Carvalho DD, Dagli ML. Constitutive androstane receptor ligands modulate the anti-tumor efficacy of Paclitaxel in non-small cell lung cancer cells. PLoS One 2014 June 24;9(6):e99484.
    PubMed | PDF

  • AC Planello, J Ji, V Sharma, R Singhania, F Mbabaali, F Müller, JA Alfaro, C Bock, DD De Carvalho, NN Batada. Aberrant DNA methylation reprogramming during induced pluripotent stem cell generation is dependent on the choice of reprogramming factors. Cell Regeneration 2014 February 7; 3:4.
    PubMed | PDF

  • JS You, DD De Carvalho, C Dai, M Liu, K Pandiyan, XJ Zhou, G Liang, PA Jones. SNF5 Is an Essential Executor of Epigenetic Regulation during Differentiation. PLoS Genetic 2013 April 25; 9(4):e1003459.
    PubMed | PDF

  • DD De Carvalho, S Sharma, JS You, SF Su, PC Taberlay, TK Kelly, X Yang, G Liang, PA Jones. DNA methylation screening identifies driver epigenetic events of cancer cell survival. Cancer Cell 2012 May 25; 21(5): 655-67.
    PubMed | PDF
    Selected as one of the most significant cancer discoveries in 2012 by ASCO (American Society of Clinical Oncology) on its Annual Report on Progress Against Cancer
    Featured as a Must Read article by Faculty of 1000 post-publication peer review
    Highlighted by Nature reviews Cancer

  • PC Taberlay, TK Kelly, CC Liu, JS You, DD De Carvalho, TB Miranda, XJ Zhou, G Liang, PA Jones. Polycomb Repressed Genes have Permissive Enhancers that Initiate Reprogramming. Cell 2011 Dec 9; 147(6): 1283-94.
    PubMed | PDF

  • JS You, TK Kelly, DD De Carvalho, PC Taberlay, G Liang, PA Jones. Nucleosome depleted regions, established by OCT4, are an additional layer of epigenetic regulation of pluripotent gene expression. PNAS 2011 Aug 30;108(35):14497-502.
    PubMed | PDF
    Featured as a Must Read article by Faculty of 1000 post-publication peer review

  • DD De Carvalho, BP Mello, GP Amarante-Mendes. PRAME/EZH2-mediated regulation of TRAIL: a new target for cancer therapy. Current Molecular Medicine 2012, in press.
    PubMed | PDF

  • S Sharma*, DD De Carvalho*, S Jeong, PA Jones, G Liang. Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance. PLoS Genetics 2011 Feb 3; 7(2):e1001286.
    PubMed | PDF
    Highlighted by Epigenomics

  • TK Kelly*, DD De Carvalho*, PA Jones. Epigenetic Modifications as Therapeutic Targets. Nature Biotechnology 2010 Oct13;28(10):1069-1078.
    PubMed | PDF
    Featured as a Hot Paper in Biology & Biochemistry by ISI Web of Knowledge

  • DD De Carvalho; R Binato, WO Pereira, JM Leroy, MD Colassanti, R Proto- Siqueira, AE Bueno-Da-Silva, MA Zago, MA Zanichelli, E Abdelhay, FA Castro, JF Jacysyn, GP Amarante-Mendes. BCR-ABL-mediated up-regulation of PRAME is responsible for knocking down TRAIL in CML patients. Oncogene 2011 Jan 13;30(2):223-33.
    PubMed | PDF
    Two major Brazilian newspapers (Correio Brasiliense and Estado de Minas) published full-page articles about this work

  • DD De Carvalho, JS You, PA Jones. DNA Methylation and Cellular Reprogramming. Trends in Cell Biology 2010 Oct;20(10):609-17
    PubMed | PDF

    *co-first authors

    Click here for the full list.