Welcome to the De Carvalho Lab
We are located at the Princess Margaret Cancer Centre, one of the top cancer research centers in the world. We are also part of the Department of Medical Biophysics at the University of Toronto, a world class university. Our research focuses on understanding the epigenetic mechanisms underlying tumorigenesis and translate this knowledge into more efficient approaches for epigenetic therapy. We use a truly multi-disciplinary approach to discovery what mechanisms are driving the cancer-specific epigenetic alterations and translating this knowledge into more efficient epigenetic interventions. To achieve this goal, we combine advanced molecular and cellular biology techniques with Next Generation Sequencing (NGS), epigenomics and computational biology.